Overview
Piperine is an alkaloid extracted from Piper nigrum, responsible for the pungency of black pepper, with uses in food flavorings, fragrances, insecticides, and traditional medicine. Its effects are mediated through the activation of TRPV1, similar to its isomer chavicine. However, it can be acutely toxic in high doses. Research by [[national-institutes-of-health|National Institutes of Health]] and studies published in [[nature|Nature]] have explored its potential health benefits and risks.